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Prednisone and Autism

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Other Therapy Options

Are there other medical therapies that restore speech / language capability?

Prednisone is a steroid; NOT the anabolic steroid that bodybuilders use, but rather a "corticosteroid", like the hydrocortisone used to treat inflammation, or to treat autoimmune disorders such as rheumatoid arthritis and asthma. Prednisone is the generic name; some common brand names are Prelone, Deltasone, Meticorten, Orasone, Prednisolone and SK-Prednisone.

Prednisone was developed in 1955 as a man-made replica of cortisone, a hormone produced by the outer portion (or cortex) of the adrenal glands, located on top of the kidneys. Cortisone and related hormones help regulate the blood pressure, salt and water balance, and controls inflammation. It may also be important for normal brain development. The adrenal glands normally produce about 25mg of cortisone a day, which is equivalent to about 5mg of prednisone a day.

When prescribed in higher doses, prednisone suppresses inflammation as well as the body’s immune system, and can help treat a variety of diseases such as severe allergies or skin problems, asthma, arthritis, ulcerative colitis, and multiple sclerosis. Prednisone is also used to help prevent rejection of organ transplants.

The original uses of steroids (dating back to 1948) were to treat immune-system diseases such as rheumatoid arthritis and polio. Over time, it became clear that it could treat many other conditions as well, and could suppress the immune system in the case of organ transplants.

Prednisone was used to treat certain childhood epilepsies in the 1970s, as it helped to reduce seizure frequency and normalize epileptic EEGs. In the 1980s, it began to be used for treatment of seizures and abnormal EEGs in LKS, infantile spasms, Lenex-Gastault syndrome (multiple seizures coupled with global delays) and related conditions, where its effects on speech recovery were noted. In the 1990s, some neurologists began using it to treat autism & Autistic Spectrum Disorders even when no seizures or EEG abnormalities were noted, first only the regressive form and later the "delayed from birth" form.

The moral here is, although its use in autism is new, prednisone has a long history behind it.

Questions or comments about Prednisone and Autism? Email us at prednisone@aheadwithautism.com.

Prednisone Menu and Links

  1. Prednisone and Autism
  2. The Diamond of Hope
  3. What Prednisone Does
  4. What is Prednisone?
  5. How Does Prednisone Work?
  6. Other Therapy Options
  7. Prednisone Effectiveness
  8. Worries and Side Effects
  9. Why Haven't I Heard More?
  10. Prescription, Procedure, Results
  11. Real Life Experiences
  12. Doctors
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